Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944825 | 0.92 | TSHR (0.52) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL3944799 | 0.90 | LMNA (0.47) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL3952786 | 0.90 | TSHR (0.57) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL3945238 | 0.88 | LMNA (0.50) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL3942061 | 0.86 | TSHR (0.45) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL13942056 | 0.86 | TSHR (0.40) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL13942589 | 0.86 | TSHR (0.45) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL13942752 | 0.86 | TSHR (0.41) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL3941820 | 0.83 | TSHR (0.41) | TSHRMAPK1TP53HTTSMN1; SMN2 | |
| SCHEMBL13942054 | 0.82 | TSHR (0.40) | TSHRMAPK1TP53HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |