Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440779 | 0.84 | CLK2 (0.42) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL3943257 | 0.77 | CLK2 (0.42) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL8127319 | 0.76 | CLK2 (0.45) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL3440741 | 0.74 | CLK2 (0.43) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL3440721 | 0.73 | CLK2 (0.41) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL4681769 | 0.73 | CLK2 (0.38) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL12101328 | 0.73 | ROCK2 (0.41) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL13104154 | 0.71 | MEN1 (0.41) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL13104213 | 0.71 | ABCB1 (0.41) | CLK2CLK3DYRK1AROCK2CYP3A4 | |
| SCHEMBL13104155 | 0.71 | MEN1 (0.41) | CLK2CLK3DYRK1AROCK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051975-B1 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| EP-2051975-A2 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | Boehringer Ingelheim International GmbH (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007131982-A2 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | WO | disclosed |