Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.80 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.80 |
| ▸ | APP | P05067 | 10/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374499 | 0.89 | APP (0.71) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL1373508 | 0.89 | AKR1C3 (1.00) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL1373495 | 0.86 | AKR1C3 (0.69) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL1373506 | 0.81 | APP (1.00) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL411735 | 0.78 | APP (0.76) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL3945107 | 0.77 | AKR1C3 (0.46) | AKR1C3AKR1C2APPSERPINE1 | |
| SCHEMBL5791300 | 0.77 | AKR1C3 (0.70) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL5790831 | 0.76 | AKR1C3 (0.49) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL5448540 | 0.74 | APP (1.00) | AKR1C3AKR1C2APPAKR1C1CYP2C9 | |
| SCHEMBL1465617 | 0.73 | KMT2A (0.48) | AKR1C3AKR1C2APPAKR1C1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046119-A2 | TREATMENT OF PSYCHIATRIC DISORDERS | Myriad Genetics, Inc. (US) | 2009-04-15 | — | — | EP | claimed |
| WO-2008006099-A2 | TREATMENT OF PSYCHIATRIC DISORDERS | MYRIAD GENETICS, INC. (US) | 2008-01-10 | — | — | WO | claimed |
| WO-2006020853-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |