Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.76 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.72 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.72 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.72 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.68 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.68 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.68 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.68 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.68 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.68 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21874201 | 0.94 | APP (0.69) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1371366 | 0.88 | APP (0.97) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL5448540 | 0.87 | APP (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL2776247 | 0.87 | APP (0.89) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL2777333 | 0.85 | APP (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1371930 | 0.85 | APP (0.82) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL7407126 | 0.84 | APP (0.56) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1373506 | 0.84 | APP (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1373508 | 0.84 | AKR1C3 (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1372754 | 0.84 | AKR1C3 (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013786-B1 | IMPROVED PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARM SPA (IT) | 2018-04-04 | — | — | EP | disclosed |
| EP-3013786-B1 | IMPROVED PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARM SPA (IT) | 2018-04-04 | — | — | EP | disclosed |
| CN-105658615-A | Improved process for the preparation of 1- (2-fluoro [1, 1' -biphenyl ] -4-yl) -cyclopropanecarboxylic acid derivatives | 奇斯药制品公司 | 2016-06-08 | — | — | CN | disclosed |
| EP-3013786-A1 | IMPROVED PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID | Chiesi Farmaceutici S.p.A. (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-9290428-B2 | Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-22 | — | — | US | disclosed |
| US-9290428-B2 | Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-22 | — | — | US | disclosed |
| US-9290428-B2 | Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-22 | — | — | US | disclosed |
| WO-2015181094-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015181094-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015181094-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DOWN'S SYNDROME | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-03 | — | — | WO | disclosed |
| WO-2011151330-A1 | 1-(2-FLUOROBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID DERIVATIVES FOR THE THERAPY OF PRION DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-08 | — | — | WO | disclosed |
| US-20110288175-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-11-24 | — | — | US | disclosed |
| US-8022250-B2 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-09-20 | — | — | US | disclosed |
| US-20110039934-A1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2- HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-02-17 | — | — | US | disclosed |
| US-20100099768-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-04-22 | — | — | US | disclosed |
| US-7662995-B2 | 1-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylic acid, for example; treatment and/or prevention of Alzheimer's disease; inhibiting the release of A beta 42 peptide thereby being able to modulate gamma-secretase activity without affecting other important metabolic processes | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-02-16 | — | — | US | disclosed |
| EP-1594833-B1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMA SPA (IT) | 2008-09-24 | — | — | EP | disclosed |
| US-20070060752-A1 | 1-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylic acid, for example; treatment and/or prevention of Alzheimer's disease; inhibiting the release of A beta 42 peptide thereby being able to modulate gamma-secretase activity without affecting other important metabolic processes | CHIESI FARMACEUTICI S.P.A. (IT) | 2007-03-15 | — | — | US | disclosed |
| EP-1594833-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.p.A. (IT) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074232-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099768-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PSEN1, SNCA, PSEN2 | APP 5/4885CYP2C9 3646/4885CYP2C19 3598/4885 |
| US-20110039934-A1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2- HALOBIPHENYL-4-YL)-CYCLOPROPANECARBOXYLIC ACID | DHPS, CYP8B1, PCCA | APP 2816/4885CYP2C9 5/4885CYP2C19 21/4885 |
| US-20070060752-A1 | 1-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylic acid, for example; treatment and/or prevention of Alzheimer's disease; inhibiting the release of A beta 42 peptide thereby being able to modulate gamma-secretase activity without affecting other important metabolic processes | BACE1, APP, BACE2 | APP 2/4885CYP2C9 1801/4885CYP2C19 1262/4885 |
| US-20110288175-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PSEN1, SNCA, PSEN2 | APP 5/4885CYP2C9 3646/4885CYP2C19 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.