Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL849127 | 0.79 | STAT6 (0.37) | EGFRITKPDE4BBTKSTAT6 | |
| SCHEMBL27800295 | 0.70 | MAPT (0.42) | PDE4BDHODHPPARGKDM4ENPC1 | |
| SCHEMBL3637778 | 0.66 | GAA (0.38) | EGFRKDM4E | |
| SCHEMBL3630787 | 0.66 | GAA (0.34) | EGFRITKBTKJAK3STAT6 | |
| SCHEMBL3634212 | 0.64 | LMNA (0.42) | PDE4BPPARGKDM4ENPC1RAB9A | |
| SCHEMBL8171612 | 0.62 | DHODH (0.57) | PDE4BDHODHNPC1RAB9A | |
| SCHEMBL847744 | 0.62 | STAT6 (0.39) | EGFRITKPDE4BBTKSTAT6 | |
| SCHEMBL846959 | 0.62 | FFAR1 (0.40) | PDE4BNAMPTSTAT6MAPK8NPC1 | |
| SCHEMBL846971 | 0.61 | STAT6 (0.38) | EGFRITKPDE4BBTKSTAT6 | |
| SCHEMBL846982 | 0.61 | MAPT (0.44) | DHODHMAPK8KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |