Fisetin

Fisetin

SCHEMBL39454

O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 10/20 1.00
KMT2A Q03164 10/20 1.00
KDM4E B2RXH2 8/20 1.00
CYP3A4 P08684 8/20 1.00
HSD17B10 Q99714 8/20 1.00
MAPT P10636 7/20 1.00
TP53 P04637 6/20 1.00
ALOX15 P16050 6/20 1.00
CYP2C9 P11712 6/20 1.00
MAPK1 P28482 5/20 1.00
RECQL P46063 5/20 1.00
CASP1 P29466 4/20 1.00
CASP7 P55210 4/20 1.00
ALDH1A1 P00352 4/20 1.00
HPGD P15428 4/20 1.00
CDK5 Q00535 3/20 1.00
CDK5R1 Q15078 3/20 1.00
LMNA P02545 3/20 1.00
ALOX12 P18054 3/20 1.00
CDK2 P24941 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fisetin SCHEMBL116861 1.00 MEN1 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL29381611 1.00 MEN1 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL29394036 1.00 MEN1 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL29349742 1.00 MEN1 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL4263659 0.99 CDK5 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10
Robinetin SCHEMBL9063852 0.96 MEN1 (0.92) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL4466733 0.95 MEN1 (0.90) MEN1KMT2AKDM4ECYP3A4HSD17B10
Fisetin SCHEMBL4887417 0.90 MEN1 (0.81) MEN1KMT2AKDM4ECYP3A4HSD17B10
SCHEMBL505584 0.88 MEN1 (0.79) MEN1KMT2AKDM4ECYP3A4HSD17B10
Robinetin SCHEMBL29883566 0.88 MEN1 (1.00) MEN1KMT2AKDM4ECYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9296 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12629336-B2 Compositions and methods of use thereof for treatment of mastitis CUREMAST, INC. (US) 2026-05-19 US claimed
US-20260130395-A1 Water Dispersible Botanical Compositions AQUILA BLACK LTD (AU) 2026-05-14 US claimed
EP-4727563-A1 AGENTS FOR USE IN A METHOD OF TREATING AN ACUTE LIVER DISEASE SUBJECT Beatson Institute for Cancer Research (GB) 2026-04-22 EP claimed
EP-4724079-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Stealth BioTherapeutics Inc. (US) 2026-04-15 EP claimed
EP-4482527-B1 CYTOTOXICITY TARGETING CHIMERAS FOR C-C CHEMOKINE RECEPTOR 2-EXPRESSING CELLS GLAXOSMITHKLINE IP DEV LTD (GB) 2026-04-08 EP claimed
EP-4719404-A2 METHODS FOR ADDRESSING INJECTION SITE REACTIONS ASSOCIATED WITH THE ADMINISTRATION OF BEVEMIPRETIDE Stealth BioTherapeutics Inc. (US) 2026-04-08 EP claimed
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS Nuchido Limited (GB) 2026-04-02 US claimed
US-20260083752-A1 PHARMACEUTICAL METHODS, COMPOSITIONS AND COMBINATIONS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2026-03-26 US claimed
EP-4007921-B1 METHOD OF DETERMINING RISK FOR CHRONIC STRESS AND STROKE UNIV NORTHWEST (ZA) 2026-03-25 EP claimed
EP-3346842-B1 STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME NOVONESIS PLANT BIOSOLUTIONS AS (DK) 2026-03-25 EP claimed
EP-0514966-B1 Dentifrice compositions containing stannous compounds UNILEVER NV (NL) 1995-07-12 EP claimed
CN-1100633-A Chondroprotective agents KUREHA CHEMICAL IND CO LTD (JP) 1995-03-29 CN claimed
EP-0633022-A2 Chondroprotective flavones KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-01-11 EP claimed
WO-1994023715-A1 USE OF FLAVONOIDS TO TREAT MULTIDRUG RESISTANT CANCER CELLS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1994-10-27 WO claimed
EP-0514966-A2 Dentifrice compositions containing stannous compounds UNILEVER N.V. (NL) 1992-11-25 EP claimed
EP-0496349-A1 Coating solution for preventing adhesion of polymer scale and method for its use SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-07-29 EP claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US claimed