Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Fisetin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.60 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.60 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.60 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 10/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.90 |
| ▸ | MAPT | P10636 | 7/20 | 0.90 |
| ▸ | TP53 | P04637 | 6/20 | 0.90 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.90 |
| ▸ | RECQL | P46063 | 5/20 | 0.90 |
| ▸ | CASP1 | P29466 | 4/20 | 0.90 |
| ▸ | CASP7 | P55210 | 4/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.90 |
| ▸ | HPGD | P15428 | 4/20 | 0.90 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fisetin SCHEMBL116861 | 0.95 | MEN1 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL39454 | 0.95 | MEN1 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL29381611 | 0.95 | MEN1 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL29394036 | 0.95 | MEN1 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL29349742 | 0.95 | MEN1 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL4263659 | 0.93 | CDK5 (1.00) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Robinetin SCHEMBL9063852 | 0.91 | MEN1 (0.92) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| Fisetin SCHEMBL4887417 | 0.85 | MEN1 (0.81) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| SCHEMBL119655 | 0.84 | MEN1 (0.73) | MEN1KMT2AKDM4ECYP3A4HSD17B10 | |
| SCHEMBL13598637 | 0.84 | MEN1 (0.67) | MEN1KMT2AKDM4ECYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158007-A2 | METHODS AND COMPOSITIONS FOR THERAPEUTIC TREATMENT | LIMERICK BIOPHARMA, INC. (US) | 2009-12-30 | — | — | WO | claimed |