Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943952 | 0.90 | HTT (0.53) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3949567 | 0.90 | HTT (0.59) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3941580 | 0.88 | HTT (0.60) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3947172 | 0.88 | HTT (0.50) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3949585 | 0.87 | TSHR (0.51) | TSHRKMT2AMEN1PTGESMMP1 | |
| SCHEMBL13942349 | 0.86 | HTT (0.54) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3950805 | 0.86 | HTT (0.48) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3946876 | 0.82 | HTT (0.66) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3949407 | 0.82 | HTT (0.69) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL3944398 | 0.81 | HTT (0.60) | HTTSMN1; SMN2ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |