Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.57 |
| ▸ | JAK2 | O60674 | 11/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942351 | 0.97 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13942371 | 0.97 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13943168 | 0.90 | JAK3 (0.60) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13943954 | 0.88 | JAK3 (0.70) | JAK3JAK2NTRK1AURKAAURKB | |
| SCHEMBL13943161 | 0.87 | JAK3 (0.51) | JAK3JAK2NTRK1PLK4AURKA | |
| SCHEMBL13943175 | 0.86 | JAK3 (0.61) | JAK3JAK2NTRK1 | |
| SCHEMBL4028491 | 0.86 | JAK2 (0.48) | JAK3JAK2NTRK1PLK4 | |
| SCHEMBL13942856 | 0.86 | JAK3 (0.48) | JAK3JAK2PLK4PAK4 | |
| SCHEMBL13942615 | 0.86 | JAK3 (0.48) | JAK3JAK2PLK4 | |
| SCHEMBL3942638 | 0.85 | JAK3 (0.47) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |