Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | IGF1R | P08069 | 9/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942351 | 0.89 | JAK3 (0.60) | JAK2JAK3PLK4NTRK1 | |
| SCHEMBL13942371 | 0.89 | JAK3 (0.60) | JAK2JAK3PLK4NTRK1 | |
| SCHEMBL3946015 | 0.86 | JAK3 (0.57) | JAK2JAK3PLK4NTRK1 | |
| SCHEMBL2162086 | 0.83 | JAK2 (0.43) | JAK2JAK3 | |
| SCHEMBL13943168 | 0.82 | JAK3 (0.60) | JAK2JAK3PLK4NTRK1 | |
| SCHEMBL13942856 | 0.81 | JAK3 (0.48) | JAK2JAK3PLK4 | |
| SCHEMBL3946105 | 0.80 | JAK3 (0.46) | JAK2JAK3IGF1RPLK4NTRK1 | |
| SCHEMBL3946100 | 0.80 | JAK3 (0.46) | JAK2JAK3IGF1RPLK4NTRK1 | |
| SCHEMBL13943434 | 0.79 | JAK3 (0.49) | JAK2JAK3PLK4NTRK1 | |
| SCHEMBL13943188 | 0.79 | JAK3 (0.49) | JAK2JAK3PLK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |