Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 17/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.55 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.54 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917924 | 0.84 | MEN1 (0.55) | FYNTGFBR1ACVR1CHEK2 | |
| SCHEMBL27799325 | 0.80 | DYRK1A (0.58) | FYNTGFBR1ACVR1CHEK2 | |
| SCHEMBL15672918 | 0.79 | MGAM (0.51) | FYN | |
| SCHEMBL28488891 | 0.78 | MAP4K4 (0.51) | FYN | |
| SCHEMBL28417539 | 0.77 | SYK (0.55) | FYNBRD4SYK | |
| SCHEMBL6974958 | 0.76 | FYN (0.55) | FYNBRD4TGFBR1BMPR1AACVRL1 | |
| SCHEMBL18613367 | 0.76 | FYN (1.00) | FYNTGFBR1BMPR1AACVRL1ACVR1 | |
| SCHEMBL18613265 | 0.75 | FYN (1.00) | FYNTGFBR1BMPR1AACVRL1ACVR1 | |
| SCHEMBL29361091 | 0.75 | FYN (0.72) | FYNTGFBR1BMPR1AACVRL1ACVR1 | |
| SCHEMBL20522368 | 0.75 | CLK4 (0.56) | FYNSYKCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347462-A1 | METHODS, COMPOSITIONS, AND USES OF NOVEL FYN KINASE INHIBITORS | Lau, Warren C. (US) | 2018-07-18 | — | — | EP | claimed |
| WO-2017044623-A1 | METHODS, COMPOSITIONS, AND USES OF NOVEL FYN KINASE INHIBITORS | LAU WARREN C (US) | 2017-03-16 | — | — | WO | claimed |
| US-20230392115-A1 | METHODS FOR MAKING AND USING DIFFERENTIATED NEURAL CELLS | RESEARCH DEVELOPMENT FOUNDATION (US) | 2023-12-07 | — | — | US | disclosed |
| EP-3122355-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | The Brigham and Women's Hospital, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148654-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-10-01 | — | — | WO | disclosed |
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |