Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | EDNRA | P25101 | 4/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942628 | 0.92 | BRD4 (0.47) | BRD4KDM4EALDH1A1SERPINE1POLB | |
| SCHEMBL3940672 | 0.89 | BRD4 (0.47) | BRD4KDM4EALDH1A1SERPINE1POLB | |
| SCHEMBL3945365 | 0.89 | BRD4 (0.55) | BRD4ALDH1A1SERPINE1POLBMEN1 | |
| SCHEMBL3940667 | 0.89 | BRD4 (0.48) | BRD4KDM4EALDH1A1SERPINE1POLB | |
| SCHEMBL4033646 | 0.89 | BRD4 (0.51) | BRD4ALDH1A1SERPINE1POLBMEN1 | |
| SCHEMBL3952979 | 0.88 | BRD4 (0.47) | BRD4KDM4EALDH1A1SERPINE1POLB | |
| SCHEMBL3952042 | 0.88 | BRD4 (0.46) | BRD4ALDH1A1SERPINE1POLBMEN1 | |
| SCHEMBL3941927 | 0.88 | BRD4 (0.48) | BRD4KDM4EALDH1A1SERPINE1POLB | |
| SCHEMBL3950711 | 0.87 | HSD11B1 (0.48) | BRD4KDM4EALDH1A1PHGDHKMT2A | |
| SCHEMBL3950164 | 0.87 | BRD4 (0.46) | BRD4ALDH1A1SERPINE1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802572-B1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-04-22 | — | — | EP | disclosed |
| EP-1802572-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006032541-A1 | INDOL DERIVATIVES AS INHIBITORS OF SOLUBLE ADENYLYL CYCLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | WO | disclosed |