Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | HTR2C | P28335 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950111 | 0.94 | ALDH1A1 (0.60) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL4032615 | 0.93 | ALDH1A1 (0.65) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL3950943 | 0.91 | HTR2A (0.59) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL3945634 | 0.90 | DRD4 (0.55) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL3945404 | 0.89 | HTR2A (0.58) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL3945494 | 0.87 | MAPT (0.61) | ALDH1A1MAPTLMNAL3MBTL1HTR2A | |
| SCHEMBL3954051 | 0.86 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNAL3MBTL1HTR2A | |
| SCHEMBL3950007 | 0.86 | HTR2A (0.62) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL4038432 | 0.86 | DRD4 (0.57) | ALDH1A1MAPTHTTLMNAL3MBTL1 | |
| SCHEMBL3950082 | 0.85 | HTR2A (0.66) | ALDH1A1MAPTHTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051978-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007136875-A2 | ACETAMIDE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |