Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.52 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.52 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351577 | 0.85 | CA1 (0.53) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL1809513 | 0.84 | PTPN1 (0.50) | PTPN1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1360224 | 0.81 | KDM4E (0.53) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL1576999 | 0.81 | CSNK2A1 (0.53) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL11447833 | 0.81 | CA1 (0.52) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL1405708 | 0.81 | CA1 (0.53) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL8343669 | 0.80 | PTPN1 (0.59) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL6064903 | 0.80 | CA1 (0.52) | PTPN1CA1CA2PTGS2CA12 | |
| SCHEMBL10652712 | 0.80 | KMT2A (0.50) | CA1CA2PTGS2CA12ALOX5 | |
| SCHEMBL18398130 | 0.80 | GSK3B (0.53) | PTPN1CTSBKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551865-B1 | HYBRID MOLECULES OF MACROLIDES WITH STEROIDAL/NON-STEROIDAL ANTI-INFLAMMATORY MOLECULES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-04-22 | — | — | EP | claimed |
| JP-55040645-A | — | — | None | — | — | JP | disclosed |
| US-5091422-A | Treating inflammatory or allergic skin disease, lowering gastric acidity | GLAXO GROUP LIMITED (GB) | 1992-02-25 | — | — | US | disclosed |
| US-4987133-A | Salicylic acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-01-22 | — | — | US | disclosed |
| EP-0338352-A2 | Salicylic acid derivatives | MERCK PATENT GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |
| US-4290954-A | ANTIALLERGENS, ANTIANAPHYLACTIC AGENTS, ANALGESICS, ANTIINFLAMMATORY AGENTS | KOWA COMPANY LIMITED (JP) | 1981-09-22 | — | — | US | disclosed |
| US-4255575-A | HYPOTENSIVE, ANTISPASMODIC, ADRENERGIC BLOCKING AGENTS | RICHARDSON-MERRELL INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4206125-A | ADENERGIC BLOCKING AGENTS, HYPOTENSIVES | RICHARDSON-MERRELL INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4200755-A | ADRENERGIC BLOCKING AGENTS, ANTISPASMODIC AGENTS, HYPOTENSIVE AGENTS | RICHARDSON-MERRELL INC. (US) | 1980-04-29 | — | — | US | disclosed |
| JP-S5540645-A | BENZOPYRONE DERIVATIVE | KOWA CO | 1980-03-22 | — | — | JP | disclosed |
| JP-S05540645-A | — | — | 0001-01-01 | — | — | JP | disclosed |