SCHEMBL3947606

SCHEMBL3947606

COc1ccc(C2NC(=O)NC(CCc3ccc(F)cc3)=C2C(=O)OCc2ccccc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.71
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3943267 1.00 RXFP1 (0.71) RXFP1MEN1KMT2A
SCHEMBL3942341 0.95 MEN1 (0.65) RXFP1MEN1KMT2A
SCHEMBL3949873 0.93 MEN1 (0.62) RXFP1MEN1KMT2A
SCHEMBL3944881 0.92 RXFP1 (0.65) RXFP1MEN1KMT2A
SCHEMBL3950017 0.92 ALDH1A1 (0.62) RXFP1MEN1KMT2A
SCHEMBL3946511 0.92 MEN1 (0.61) RXFP1MEN1KMT2A
SCHEMBL3948655 0.91 RXFP1 (0.61) RXFP1MEN1KMT2A
SCHEMBL3941722 0.91 RXFP1 (0.60) RXFP1MEN1KMT2A
SCHEMBL3950845 0.88 MEN1 (0.58) RXFP1MEN1KMT2A
SCHEMBL4521555 0.87 RXFP1 (0.59) RXFP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009020457-A2 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2009-02-12 WO disclosed