Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947135 | 0.90 | GRM5 (0.46) | GRM5NPSR1S1PR4KDM4EALDH1A1 | |
| SCHEMBL16030718 | 0.83 | NPSR1 (0.48) | GRM5NPSR1S1PR4KDM4EALDH1A1 | |
| SCHEMBL2372967 | 0.82 | NPSR1 (0.52) | GRM5NPSR1S1PR4KDM4EALDH1A1 | |
| SCHEMBL388845 | 0.81 | NPSR1 (0.50) | NPSR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL26140305 | 0.81 | NPSR1 (0.50) | NPSR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL10665321 | 0.81 | NPSR1 (0.50) | NPSR1S1PR4KDM4EALDH1A1CA12 | |
| SCHEMBL29829085 | 0.81 | NPSR1 (0.50) | NPSR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL24344299 | 0.79 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL20745210 | 0.79 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1CA12CA1 | |
| SCHEMBL29625298 | 0.79 | NPSR1 (0.48) | NPSR1KDM4EALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2023-03-09 | — | — | US | disclosed |
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |
| CN-113573708-A | Polyvalent derivatives of emoxidine | 阿尔萨泰克公司 | 2021-10-29 | — | — | CN | disclosed |
| EP-3255042-B1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | BEYONDBIO INC (KR) | 2020-12-30 | — | — | EP | disclosed |
| WO-2020163704-A1 | POLYVALENT DERIVATIVES OF EMOXYPINE | ALSATECH, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |
| WO-2019074898-A1 | DISAGGREGATION OF ALPHA-SYNUCLEIN WITH SMALL MOLECULES | ALSATECH, INC. (US) | 2019-04-18 | — | — | WO | disclosed |
| WO-2019074898-A1 | DISAGGREGATION OF ALPHA-SYNUCLEIN WITH SMALL MOLECULES | ALSATECH, INC. (US) | 2019-04-18 | — | — | WO | disclosed |
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230069963-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | ZC3HAV1, ZC3HAV1L, IL5 | GRM5 882/4885NPSR1 3111/4885S1PR4 121/4885 |
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | GRM5 319/4885NPSR1 529/4885S1PR4 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.