Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068578 | 0.81 | L3MBTL3 (0.39) | HTR6L3MBTL3L3MBTL1 | |
| SCHEMBL5068015 | 0.79 | L3MBTL3 (0.39) | MEN1KMT2AL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL3338552 | 0.76 | SLC18A3 (0.38) | SLC18A3OPRM1OPRL1POLBHSD17B10 | |
| SCHEMBL20096220 | 0.74 | HRH3 (0.44) | SLC18A3OPRM1OPRL1POLBHSD17B10 | |
| SCHEMBL26170 | 0.73 | — | — | |
| SCHEMBL13942560 | 0.73 | PHGDH (0.52) | SLC18A3POLBHSD17B10HRH3KCNH2 | |
| SCHEMBL19034085 | 0.73 | — | — | |
| SCHEMBL24511688 | 0.71 | L3MBTL3 (0.52) | SLC18A3OPRM1OPRL1HTR6L3MBTL3 | |
| SCHEMBL15321 | 0.71 | — | — | |
| SCHEMBL18946139 | 0.71 | L3MBTL3 (0.52) | SLC18A3OPRM1OPRL1HTR6L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018387-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007115933-A1 | THIAZOLYLDIHYDROINDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |