Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.45 |
| ▸ | AKT2 | P31751 | 4/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194052 | 0.84 | AKT1 (0.47) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL16250555 | 0.84 | AKT1 (0.47) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL16250556 | 0.83 | AKT1 (0.49) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL16488556 | 0.82 | AKT2 (0.48) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL16250573 | 0.81 | AKT1 (0.48) | AKT1AKT2AKT3SMN1; SMN2HTT | |
| SCHEMBL3944642 | 0.80 | AKT1 (0.44) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL22533475 | 0.80 | AKT1 (0.44) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL8220458 | 0.80 | AKT1 (0.47) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2262653 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2262657 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694485-A1 | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE | Genentech, Inc. (US) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012135750-A1 | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE | GENENTECH, INC. (US) | 2012-10-04 | — | — | WO | disclosed |
| EP-2049500-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006032-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |