Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.47 |
| ▸ | AKT2 | P31751 | 5/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194052 | 0.83 | AKT1 (0.47) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL16250555 | 0.83 | AKT1 (0.47) | AKT1AKT2AKT3LMNAHTT | |
| Hydrochloric Acid SCHEMBL27905413 | 0.83 | AKT1 (0.56) | AKT1AKT2AKT3 | |
| SCHEMBL16250556 | 0.82 | AKT1 (0.49) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL16488556 | 0.81 | AKT2 (0.48) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL16131674 | 0.80 | AKT1 (0.56) | AKT1AKT2AKT3KDM4E | |
| SCHEMBL27905414 | 0.80 | AKT1 (0.56) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL3117947 | 0.80 | AKT1 (0.56) | AKT1AKT2AKT3LMNASMN1; SMN2 | |
| SCHEMBL3948397 | 0.80 | AKT1 (0.45) | AKT1AKT2AKT3LMNAHTT | |
| SCHEMBL16250573 | 0.80 | AKT1 (0.48) | AKT1AKT2AKT3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023187037-A1 | EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TYROSINE KINASE INHIBITORS IN COMBINATION WITH AN AKT INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-10-05 | — | — | WO | disclosed |
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |