Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.42 |
| ▸ | AKT2 | P31751 | 4/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944415 | 0.90 | AKT1 (0.43) | AKT1AKT2AKT3 | |
| SCHEMBL3976015 | 0.88 | AKT1 (0.57) | AKT1 | |
| SCHEMBL3943213 | 0.86 | AKT1 (0.46) | AKT1AKT2AKT3 | |
| SCHEMBL2522372 | 0.79 | AKT1 (0.61) | AKT1AKT2AKT3 | |
| SCHEMBL2522376 | 0.79 | AKT1 (0.61) | AKT1AKT2AKT3 | |
| SCHEMBL2263420 | 0.79 | AKT1 (0.46) | AKT1AKT2AKT3MAPK1 | |
| Hydrochloric Acid SCHEMBL2266705 | 0.79 | AKT1 (0.60) | AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL2266713 | 0.79 | AKT1 (0.60) | AKT1AKT2AKT3 | |
| SCHEMBL2262878 | 0.79 | AKT1 (0.47) | AKT1AKT2AKT3MAPK1 | |
| SCHEMBL2421335 | 0.78 | AKT1 (0.52) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006032-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |