Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978920 | 0.90 | AKT1 (0.67) | AKT1 | |
| SCHEMBL3948629 | 0.88 | AKT1 (0.42) | AKT1 | |
| SCHEMBL3943213 | 0.84 | AKT1 (0.46) | AKT1 | |
| SCHEMBL14330250 | 0.80 | AKT1 (0.81) | AKT1 | |
| SCHEMBL14330235 | 0.80 | AKT1 (0.81) | AKT1 | |
| SCHEMBL2573575 | 0.80 | AKT1 (0.60) | AKT1 | |
| Hydrochloric Acid SCHEMBL2576098 | 0.79 | AKT1 (0.80) | AKT1 | |
| Hydrochloric Acid SCHEMBL2576094 | 0.79 | AKT1 (0.80) | AKT1 | |
| SCHEMBL2577390 | 0.79 | AKT1 (0.63) | AKT1 | |
| SCHEMBL3944415 | 0.77 | AKT1 (0.43) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |