Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 5/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945732 | 0.90 | CTSL (0.43) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3947845 | 0.89 | CTSL (0.44) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3948965 | 0.87 | CTSL (0.46) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL4303295 | 0.86 | CTSL (0.41) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3949206 | 0.85 | CTSL (0.39) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3948764 | 0.85 | CTSL (0.39) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3950848 | 0.84 | CTSL (0.43) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3954933 | 0.84 | CTSL (0.38) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3956823 | 0.84 | KMT2A (0.39) | CTSLCTSSCTSKCTSCALDH1A1 | |
| SCHEMBL3952105 | 0.84 | CTSL (0.48) | CTSLCTSSCTSKCTSCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |