Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763206 | 0.89 | KCNA5 (0.79) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3749185 | 0.88 | KCNA5 (0.54) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3758930 | 0.86 | KCNA5 (0.57) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3754129 | 0.83 | KCNA5 (0.53) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3755379 | 0.80 | KCNA5 (0.50) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3755943 | 0.76 | KCNA5 (1.00) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3751958 | 0.75 | KCNA5 (0.82) | KCNA5KCNH2SCN9ASCN5ATDP1 | |
| SCHEMBL3745343 | 0.75 | KCNA5 (0.78) | KCNA5TSHRKCNH2SCN9ASCN5A | |
| SCHEMBL3750669 | 0.74 | KCNA5 (0.86) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL4030993 | 0.74 | KCNA5 (0.51) | KCNA5TSHRHTTL3MBTL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |