Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757051 | 0.87 | KCNA5 (0.45) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3754098 | 0.84 | TSHR (0.51) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3751187 | 0.83 | KCNA5 (0.53) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3948892 | 0.74 | KCNA5 (0.61) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3754031 | 0.73 | KCNA5 (0.60) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3752544 | 0.72 | KCNA5 (0.63) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3755711 | 0.71 | KCNA5 (0.58) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3753809 | 0.71 | KCNA5 (0.53) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3760632 | 0.68 | KCNA5 (0.60) | KCNA5TSHRHTTL3MBTL1KCNH2 | |
| SCHEMBL3751695 | 0.68 | KCNA5 (0.72) | KCNA5TSHRHTTL3MBTL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |