SCHEMBL3949151

SCHEMBL3949151

CC(C)S(=O)(=O)c1ccccc1Nc1nc(N)nc(Cl)c1Cl

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK7 P50613 11/20 0.51
CDK9 P50750 11/20 0.51
ALK Q9UM73 8/20 0.50
HDAC1 Q13547 1/20 0.47
MET P08581 4/20 0.46
INSR P06213 1/20 0.45
ROS1 P08922 2/20 0.45
AURKA O14965 1/20 0.45
NTRK1 P04629 1/20 0.45
IGF1R P08069 1/20 0.45
CDK4 P11802 1/20 0.45
EPHA1 P21709 1/20 0.45
CDK2 P24941 1/20 0.45
CDK3 Q00526 1/20 0.45
CDK6 Q00534 1/20 0.45
CDK5 Q00535 1/20 0.45
EGFR P00533 1/20 0.45
DCLK1 O15075 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3959009 0.88 ALK (0.51) CDK7CDK9ALKHDAC1MET
SCHEMBL3953087 0.85 ALK (0.51) CDK7CDK9ALKINSRAURKA
SCHEMBL3959979 0.84 CDK7 (0.50) CDK7CDK9ALKHDAC1MET
SCHEMBL12862540 0.82 CDK7 (0.66) CDK7CDK9ALKHDAC1MET
SCHEMBL3954082 0.82 ALK (0.55) CDK7CDK9ALKHDAC1MET
Hydrochloric Acid SCHEMBL30817651 0.81 CDK7 (0.64) CDK7CDK9ALKHDAC1MET
SCHEMBL3958857 0.81 ALK (0.54) CDK7CDK9ALKHDAC1MET
SCHEMBL31174012 0.78 TTK (0.66) CDK7CDK9ALKINSRIGF1R
SCHEMBL1493586 0.78 ALK (0.51) CDK7CDK9ALKHDAC1MET
SCHEMBL30156784 0.78 CDK9 (0.63) CDK7CDK9ALKHDAC1MET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009032703-A1 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS IRM LLC (BM) 2009-03-12 WO disclosed
WO-2009032694-A1 AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS DANA FARBER CANCER INSTITUTE (US) 2009-03-12 WO disclosed
WO-2009032703-A1 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS IRM LLC (BM) 2009-03-12 WO disclosed