Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 15/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956922 | 0.96 | ATR (0.41) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3948659 | 0.87 | ATR (0.42) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3948852 | 0.86 | ATR (0.41) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3954127 | 0.85 | ATR (0.38) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3948208 | 0.84 | ATR (0.40) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3951611 | 0.83 | ATR (0.51) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3954987 | 0.82 | ATR (0.38) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3949893 | 0.78 | EGFR (0.44) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3949584 | 0.77 | ATR (0.40) | WNT1TGFBR1ATRCDK1CDK2 | |
| SCHEMBL3950242 | 0.75 | EGFR (0.42) | ATRCDK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |