Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954226 | 0.87 | CTSL (0.40) | MAPTKDM4ETDP1CTSLCTSS | |
| SCHEMBL3955269 | 0.84 | CTSL (0.39) | NPC1RAB9AHPGDSMN1; SMN2CTSL | |
| SCHEMBL3950831 | 0.83 | CTSL (0.43) | LMNAKDM4ESMN1; SMN2CTSLCTSS | |
| SCHEMBL3954708 | 0.83 | CTSL (0.38) | MAPTNPC1RAB9ALMNAHPGD | |
| SCHEMBL3954832 | 0.82 | CTSL (0.39) | MAPTNPC1CTSLCTSSCTSK | |
| SCHEMBL3944081 | 0.82 | CTSL (0.39) | MAPTNPC1RAB9AP2RX7LMNA | |
| SCHEMBL3951319 | 0.81 | CTSL (0.44) | MAPTLMNAKDM4ESMN1; SMN2CTSL | |
| SCHEMBL3949052 | 0.80 | CTSL (0.46) | MAPTLMNAKDM4ESMN1; SMN2CTSL | |
| SCHEMBL3948515 | 0.80 | CTSL (0.45) | MAPTLMNAKDM4ECTSLCTSS | |
| SCHEMBL3949447 | 0.80 | CTSL (0.41) | MAPTKDM4ECTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |