Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 2/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.54 |
| ▸ | INSR | P06213 | 5/20 | 0.54 |
| ▸ | NPM1 | P06748 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TTK | P33981 | 4/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CASK | O14936 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959984 | 0.90 | FES (0.80) | FESFLT3ALKINSRNPM1 | |
| SCHEMBL18018899 | 0.87 | ALK (0.53) | FESFLT3ALKINSRTTK | |
| SCHEMBL3953378 | 0.85 | ALK (0.55) | FESFLT3ALKINSRTTK | |
| SCHEMBL3954360 | 0.83 | FES (0.86) | FESFLT3ALKINSRTTK | |
| SCHEMBL3952863 | 0.81 | ALK (0.75) | FESFLT3ALKINSRNPM1 | |
| SCHEMBL3950992 | 0.80 | ZAP70 (0.63) | FESFLT3ALKINSRTTK | |
| SCHEMBL3958582 | 0.80 | FES (0.87) | FESFLT3ALKINSRNPM1 | |
| SCHEMBL3954048 | 0.80 | FES (1.00) | FESFLT3ALKINSRNPM1 | |
| SCHEMBL3951761 | 0.79 | ALK (0.61) | FESFLT3ALKINSRTTK | |
| SCHEMBL4051190 | 0.78 | FES (0.72) | FESFLT3ALKINSRNPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | claimed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |