Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.75 |
| ▸ | IGF1R | P08069 | 11/20 | 0.75 |
| ▸ | INSR | P06213 | 11/20 | 0.75 |
| ▸ | FES | P07332 | 4/20 | 0.72 |
| ▸ | FLT3 | P36888 | 4/20 | 0.72 |
| ▸ | EGFR | P00533 | 7/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.65 |
| ▸ | PTK2B | Q14289 | 4/20 | 0.65 |
| ▸ | STK10 | O94804 | 3/20 | 0.65 |
| ▸ | ABL1 | P00519 | 3/20 | 0.65 |
| ▸ | LCK | P06239 | 3/20 | 0.65 |
| ▸ | FYN | P06241 | 3/20 | 0.65 |
| ▸ | YES1 | P07947 | 3/20 | 0.65 |
| ▸ | HCK | P08631 | 3/20 | 0.65 |
| ▸ | ROS1 | P08922 | 3/20 | 0.65 |
| ▸ | FER | P16591 | 3/20 | 0.65 |
| ▸ | LTK | P29376 | 3/20 | 0.65 |
| ▸ | FRK | P42685 | 3/20 | 0.65 |
| ▸ | BTK | Q06187 | 3/20 | 0.65 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953410 | 0.93 | FES (0.82) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL3954360 | 0.91 | FES (0.86) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL4045834 | 0.87 | FES (0.84) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL18018887 | 0.86 | ALK (0.76) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL22985890 | 0.85 | FES (0.60) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL3959984 | 0.84 | FES (0.80) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL22985861 | 0.84 | FES (0.59) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL3954048 | 0.84 | FES (1.00) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL13395587 | 0.84 | ALK (0.85) | ALKIGF1RINSRFESFLT3 | |
| SCHEMBL19867180 | 0.84 | ALK (0.75) | ALKIGF1RINSRFESFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | claimed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |