Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.68 |
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.60 |
| ▸ | MUSK | O15146 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | STAT5B | P51692 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983768 | 0.92 | JAK3 (0.68) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL3950465 | 0.87 | NTRK1 (0.53) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL220867 | 0.86 | JAK2 (0.72) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL3338612 | 0.85 | NTRK1 (0.69) | JAK3JAK2NTRK1AURKBRET | |
| SCHEMBL3033142 | 0.85 | NTRK1 (0.78) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL14041435 | 0.81 | JAK2 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL2335570 | 0.80 | KCNH2 (0.68) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL3670155 | 0.80 | KCNH2 (0.68) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL14041700 | 0.79 | JAK2 (1.00) | JAK3JAK2NTRK1CDK2AURKB | |
| SCHEMBL3424084 | 0.78 | JAK3 (1.00) | JAK3JAK2NTRK1CDK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA R&D (SE) | 2010-08-19 | — | — | US | disclosed |
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ABL1, FLT3, ERBB2 | JAK3 73/4885JAK2 32/4885NTRK1 574/4885 |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ABL1, FLT3, ERBB2 | JAK3 73/4885JAK2 32/4885NTRK1 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.