Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 11/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751057 | 0.93 | SCN9A (0.66) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3941288 | 0.91 | SCN9A (0.54) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3756454 | 0.88 | P2RX7 (0.57) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3747617 | 0.88 | SCN9A (0.53) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3949592 | 0.87 | SCN9A (0.56) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3751622 | 0.86 | SCN9A (0.62) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3759970 | 0.86 | SCN9A (0.65) | SCN9ASCN5AKCNH2KCNA5KCNQ2 | |
| SCHEMBL3746039 | 0.86 | P2RX7 (0.61) | SCN9ASCN5AKCNH2KCNA5ALDH1A1 | |
| SCHEMBL3748526 | 0.85 | KCNA5 (0.67) | SCN9ASCN5AKCNH2TDP1KCNA5 | |
| SCHEMBL3758861 | 0.84 | SCN9A (0.54) | SCN9ASCN5AKCNH2TDP1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |