Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.81 |
| ▸ | MAPT | P10636 | 11/20 | 0.81 |
| ▸ | NPC1 | O15118 | 11/20 | 0.81 |
| ▸ | RAB9A | P51151 | 11/20 | 0.81 |
| ▸ | MEN1 | O00255 | 10/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.74 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.74 |
| ▸ | RELA | Q04206 | 4/20 | 0.74 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.60 |
| ▸ | STAT1 | P42224 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307056 | 0.82 | MAPT (0.82) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL20820669 | 0.81 | MAPT (0.81) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL3951197 | 0.80 | NPC1 (0.69) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL5027241 | 0.79 | RAB9A (0.80) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL2759505 | 0.79 | MAPT (0.86) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL14880886 | 0.78 | MAPT (0.84) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL14808176 | 0.78 | SCD (0.83) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4360717 | 0.77 | BRAF (0.70) | — | |
| SCHEMBL17287687 | 0.75 | CSNK1D (1.00) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL8280120 | 0.75 | NPC1 (0.70) | SMN1; SMN2MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029617-A1 | DIARYLAMINE-SUBSTITUTED QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |