Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.88 |
| ▸ | DAO | P14920 | 1/20 | 0.88 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.88 |
| ▸ | CES2 | O00748 | 3/20 | 0.70 |
| ▸ | CES1 | P23141 | 3/20 | 0.70 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL27673737 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL16486485 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL120680 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL27721786 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1065043 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL21634192 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL21634193 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1813391 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL36721 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL9396733 | 0.97 | TSHR (0.93) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747579-A | ACRYLIC ACID-BUTADIENE-STYRENE TERPOLYMER AND LATENT CROSSLINKING AGENT OF ZINC AMMONIUM BENZOATE AND ZINC AMMONIUM CITRATE | W.R. GRACE & CO.-CONN. (US) | 1998-05-05 | — | — | US | claimed |
| EP-0378668-B1 | CONTAINER SEALING COMPOSITIONS | W.R. Grace & Co.-Conn. (US) | 1992-09-23 | — | — | EP | claimed |
| EP-0378668-A1 | CONTAINER SEALING COMPOSITIONS. | GRACE W R & CO (US) | 1990-07-25 | — | — | EP | claimed |
| WO-1990000186-A1 | CONTAINER SEALING COMPOSITIONS | W.R. GRACE & CO.-CONN. (US) | 1990-01-11 | — | — | WO | claimed |
| EP-0350204-A1 | Container sealing compositions | W.R. Grace & Co.-Conn. (US) | 1990-01-10 | — | — | EP | claimed |
| EP-1901708-B1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING OLOPATADINE | SENJU PHARMA CO (JP) | 2013-09-11 | — | — | EP | disclosed |
| US-8101654-B2 | Percutaneously absorptive ophthalmic preparation comprising olopatadine | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2012-01-24 | — | — | US | disclosed |
| US-20090209632-A1 | Percutaneously Absorptive Ophthalmic Preparation Comprising Olopatadine | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2009-08-20 | — | — | US | disclosed |
| US-20090143359-A1 | Percutaneously Absorptive Ophthalmic Preparation Comprising Epinastine | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
| EP-1901708-A1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING OLOPATADINE | Senju Pharmaceutical Co., Ltd. (JP) | 2008-03-26 | — | — | EP | disclosed |
| EP-1901724-A1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE | Senju Pharmaceutical Co., Ltd. (JP) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007007851-A1 | PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2007-01-18 | — | — | WO | disclosed |
| EP-0350204-A1 | Container sealing compositions | W.R. Grace & Co.-Conn. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0196792-B1 | PROCESS FOR PROVIDING A CONTAINER CLOSURE. | W.R. Grace & Co.-Conn. (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4699810-A | Sealing compositions | W. R. GRACE & CO. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0196792-A1 | Process for providing a container closure. | W.R. Grace & Co.-Conn. (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0083978-B1 | POLYMER COMPOSITIONS AND THEIR USE IN OR AS ADHESIVE AND OTHER COMPOSITIONS | ROHM AND HAAS COMPANY (US) | 1986-01-08 | — | — | EP | disclosed |
| US-4423182-A | CARBOXYLIC CONTAINING POLYMER WITH METAL SALT OF O-METHOXY ARYL ACID | ROHM AND HAAS COMPANY (US) | 1983-12-27 | — | — | US | disclosed |
| EP-0083978-A1 | Polymer compositions and their use in or as adhesive and other compositions | ROHM AND HAAS COMPANY (US) | 1983-07-20 | — | — | EP | disclosed |
| US-4360638-A | CARBOXYLIC ACID POLYMER, METAL SALT, O-METHOXYARYLCARBOXYLIC ACID | ROHM AND HAAS COMPANY (US) | 1982-11-23 | — | — | US | disclosed |