Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 16/20 | 0.59 |
| ▸ | INSR | P06213 | 13/20 | 0.58 |
| ▸ | IGF1R | P08069 | 13/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985873 | 0.87 | FES (0.62) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL28479268 | 0.86 | ALK (0.79) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL22985890 | 0.86 | FES (0.60) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL3953410 | 0.85 | FES (0.82) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL21099681 | 0.84 | ALK (0.59) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL3952863 | 0.84 | ALK (0.75) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL22985944 | 0.81 | LRRK2 (0.52) | FESFLT3LRRK2DCLK1MAPK7 | |
| SCHEMBL21099500 | 0.80 | ALK (0.59) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL22985878 | 0.80 | FES (0.61) | FESFLT3ALKINSRIGF1R | |
| SCHEMBL4045834 | 0.78 | FES (0.84) | FESFLT3ALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |