Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955081 | 0.83 | OPRL1 (0.51) | POLBOPRM1OPRK1OPRL1KMT2A | |
| SCHEMBL3952571 | 0.83 | OPRL1 (0.43) | CYP1A2CYP2C19OPRM1OPRK1OPRL1 | |
| SCHEMBL4168465 | 0.81 | OPRL1 (0.44) | POLBOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL4169761 | 0.77 | OPRL1 (0.48) | POLBOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL4974510 | 0.77 | CNR1 (0.49) | CYP1A2POLBCYP3A4CYP2C19AKR1B1 | |
| SCHEMBL4979970 | 0.76 | AKR1B1 (0.41) | CYP1A2POLBCYP3A4CYP2C19AKR1B1 | |
| SCHEMBL4979166 | 0.76 | CYP1A2 (0.39) | CYP1A2POLBCYP3A4CYP2C19AKR1B1 | |
| SCHEMBL4979426 | 0.76 | CNR1 (0.51) | CYP1A2POLBCYP3A4CYP2C19AKR1B1 | |
| SCHEMBL4177865 | 0.75 | OPRL1 (0.41) | POLBOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL3953438 | 0.75 | CYP1A2 (0.43) | CYP1A2POLBCYP3A4CYP2C19OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013216-A2 | NOVEL SPIRO [IMIDAZOLIDINE-4, 3' -INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007091948-A2 | NOVEL SPIRO [IMIDAZOLIDINE-4, 3´-INDOLE] 2, 2´,5´(1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | disclosed |