Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979970 | 0.83 | AKR1B1 (0.41) | CNR1ALDH1A1SMN1; SMN2AKR1B1MEN1 | |
| SCHEMBL4979166 | 0.81 | CYP1A2 (0.39) | ALDH1A1MAPTSMN1; SMN2AKR1B1MEN1 | |
| SCHEMBL4255427 | 0.80 | MAPT (0.45) | CNR1ALDH1A1MAPTSMN1; SMN2FAAH | |
| SCHEMBL4974510 | 0.79 | CNR1 (0.49) | CNR1ALDH1A1MAPTAKR1B1MEN1 | |
| SCHEMBL3953441 | 0.76 | CYP1A2 (0.40) | ALDH1A1SMN1; SMN2AKR1B1MEN1KMT2A | |
| SCHEMBL4979616 | 0.74 | KMT2A (0.37) | CNR1ALDH1A1MAPTSMN1; SMN2AKR1B1 | |
| SCHEMBL4979421 | 0.73 | CYP1A2 (0.42) | ALDH1A1MAPTSMN1; SMN2AKR1B1MEN1 | |
| SCHEMBL4976844 | 0.73 | KMT2A (0.38) | MAPTAKR1B1KMT2ACYP1A2POLB | |
| SCHEMBL4977919 | 0.72 | KMT2A (0.40) | ALDH1A1MEN1KMT2APOLBCYP3A4 | |
| SCHEMBL3960401 | 0.71 | AKR1B1 (0.41) | ALDH1A1SMN1; SMN2AKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | claimed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |