SCHEMBL3954121

SCHEMBL3954121

O=C1C=CC2CCNC2=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6990535 0.88
SCHEMBL25381783 0.60 TLR4 (0.33)
SCHEMBL5333757 0.58 TLR4 (0.40)
Benzoquinone SCHEMBL27703628 0.51 ALDH1A1 (0.61)
SCHEMBL12168346 0.51 ALDH1A1 (0.50)
Benzoquinone SCHEMBL29262432 0.51 ALDH1A1 (0.61)
SCHEMBL30915787 0.50
SCHEMBL19348395 0.50
SCHEMBL20332219 0.50
SCHEMBL1457363 0.49

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107011237-A A kind of synthetic method of improved Molindone 合肥立方制药股份有限公司 2017-08-04 CN claimed
CN-107011237-A A kind of synthetic method of improved Molindone 合肥立方制药股份有限公司 2017-08-04 CN disclosed
CN-107011237-A A kind of synthetic method of improved Molindone 合肥立方制药股份有限公司 2017-08-04 CN disclosed
EP-1715921-A4 TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS ABRAXIS BIOSCIENCE INC (US) 2009-07-15 EP disclosed
WO-2008020180-A2 METHODS OF INCREASING THE SENSITIVITY OF CANCER CELLS TO DNA DAMAGE KUDOS PHARMACEUTICALS LIMITED (GB) 2008-02-21 WO disclosed
EP-1715921-A2 TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS Cenomed, Inc. (US) 2006-11-02 EP disclosed
EP-1684736-A1 DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER Kudos Pharmaceuticals Limited (GB) 2006-08-02 EP disclosed
WO-2005053662-A1 DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER KUDOS PHARMACEUTICALS LIMITED (GB) 2005-06-16 WO disclosed
WO-2005030148-A2 TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS CENOMED, INC. (US) 2005-04-07 WO disclosed
US-6395766-B1 COGNITION ACTIVATORS MERCK SHARP & DOHME LIMITED (GB) 2002-05-28 US disclosed
WO-1999062899-A1 TETRAHYDROINDOLONE DERIVATIVES AS GABAAALPHA5 LIGANDS FOR ENHANCING COGNITION MERCK SHARP & DOHME LIMITED (GB) 1999-12-09 WO disclosed