Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857630 | 0.86 | POLB (0.46) | MAPTBCL2BAK1ALDH1A1KDM4E | |
| SCHEMBL10175120 | 0.86 | POLB (0.46) | MAPTBCL2BAK1ALDH1A1KDM4E | |
| SCHEMBL3956681 | 0.85 | GAA (0.53) | SMN1; SMN2LMNABCL2BAK1CNR1 | |
| SCHEMBL3954451 | 0.83 | BCL2 (0.51) | SMN1; SMN2BCL2BAK1ALDH1A1KDM4E | |
| SCHEMBL3962306 | 0.82 | POLB (0.48) | SMN1; SMN2LMNAMAPTTDP1ALDH1A1 | |
| SCHEMBL13906605 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAMAPTTDP1ALDH1A1 | |
| SCHEMBL377924 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL10226374 | 0.80 | BCL2 (0.49) | MAPTBCL2BAK1ALDH1A1KDM4E | |
| SCHEMBL10175099 | 0.79 | POLB (0.45) | MAPTBCL2BAK1ALDH1A1KDM4E | |
| SCHEMBL31450904 | 0.79 | POLB (0.45) | MAPTBCL2BAK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |