Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 15/20 | 0.51 |
| ▸ | BAK1 | Q16611 | 7/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 10/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958390 | 0.86 | BCL2 (0.52) | BCL2BAK1BCL2L1 | |
| SCHEMBL10226374 | 0.86 | BCL2 (0.49) | BCL2BAK1BCL2L1POLBMEN1 | |
| SCHEMBL1743631 | 0.84 | BCL2 (0.68) | BCL2BAK1BCL2L1KDM4E | |
| SCHEMBL3955002 | 0.83 | SMN1; SMN2 (0.46) | BCL2BAK1POLBMEN1KMT2A | |
| SCHEMBL13906602 | 0.83 | BCL2 (0.47) | BCL2BAK1BCL2L1POLBMEN1 | |
| SCHEMBL13906609 | 0.82 | MEN1 (0.49) | POLBMEN1ABL1KMT2ARIN1 | |
| SCHEMBL3959612 | 0.82 | KMT2A (0.49) | POLBMEN1ABL1KMT2ARIN1 | |
| SCHEMBL30857630 | 0.80 | POLB (0.46) | BCL2BAK1POLBMEN1KMT2A | |
| SCHEMBL10175120 | 0.80 | POLB (0.46) | BCL2BAK1POLBMEN1KMT2A | |
| SCHEMBL3962996 | 0.80 | SMN1; SMN2 (0.56) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009036035-A1 | BCL-2 INHIBITORS | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |