Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL28144090 | 0.89 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL12827962 | 0.86 | KMT2A (0.64) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL14096488 | 0.84 | MAPT (0.62) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL1477785 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL14070483 | 0.84 | ALDH1A1 (0.70) | SMN1; SMN2CYP2D6HTTALDH1A1LMNA | |
| SCHEMBL2399935 | 0.83 | HTT (0.96) | SMN1; SMN2HTTKMT2AALDH1A1POLB | |
| SCHEMBL4961311 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL6387343 | 0.83 | CYP2D6 (1.00) | SMN1; SMN2CYP2D6KMT2AALDH1A1TSHR | |
| SCHEMBL28336050 | 0.83 | CYP2D6 (0.71) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 | |
| SCHEMBL1258725 | 0.83 | CYP2D6 (0.67) | SMN1; SMN2CYP2D6HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017157882-A1 | SERINE BIOSYNTHETIC PATHWAY INHIBITORS | Université Catholique de Louvain (BE) | 2017-09-21 | — | — | WO | claimed |
| US-7507732-B2 | Cyclopentapyridine and tetrahydroquinoline derivatives | PFIZER INC. (US) | 2009-03-24 | — | — | US | claimed |
| CN-110637077-B | Lubricating oil composition for internal combustion engine | JXTG能源株式会社 | 2022-09-09 | — | — | CN | disclosed |
| WO-2017157882-A1 | SERINE BIOSYNTHETIC PATHWAY INHIBITORS | Université Catholique de Louvain (BE) | 2017-09-21 | — | — | WO | disclosed |
| WO-2017157882-A1 | SERINE BIOSYNTHETIC PATHWAY INHIBITORS | Université Catholique de Louvain (BE) | 2017-09-21 | — | — | WO | disclosed |
| CN-106573915-A | Compounds active against bromodomains | 纽韦卢森公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-1926108-B | Non-nucleotide reverse transcriptase inhibitors | MEDIVIR AB | 2010-06-09 | — | — | CN | disclosed |
| CN-1926108-A | Non-nucleotide reverse transcriptase inhibitors | MEDIVIR AB (SE) | 2007-03-07 | — | — | CN | disclosed |
| EP-0035619-A1 | Derivatives of 3-amino-(1H,3H)-2,4-quinazolin-diones | BERRI-BALZAC Société dite: (FR) | 1981-09-16 | — | — | EP | disclosed |