Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29465194 | 0.98 | HTT (0.55) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17926382 | 0.98 | HTT (0.55) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL322540 | 0.98 | HTT (0.55) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17926383 | 0.96 | RAD52 (0.53) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4264829 | 0.96 | RAD52 (0.53) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3955451 | 0.96 | HTT (0.53) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| SCHEMBL29394041 | 0.96 | HTT (0.57) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| SCHEMBL296028 | 0.96 | HTT (0.57) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28953622 | 0.95 | RAD52 (0.52) | RAD52MAPTKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9362517 | 0.94 | HTT (0.60) | RAD52MAPTKDM4EAPAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511166-B2 | Process for the preparation of organylhydrogensilanes | WACKER CHEMIE AG (DE) | 2009-03-31 | — | — | US | disclosed |
| US-20060241272-A1 | Process for the preparation of organylhydrogensilanes | WACKER CHEMIE AG (DE) | 2006-10-26 | — | — | US | disclosed |