Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956608 | 0.83 | NPC1 (0.61) | APPJAK2METAP1PPP1CAKMT2A | |
| SCHEMBL3955508 | 0.80 | ATR (0.49) | APPJAK2METAP1PPP1CAKMT2A | |
| SCHEMBL3955491 | 0.78 | APP (0.48) | APPJAK2METAP1PPP1CAKMT2A | |
| SCHEMBL3955753 | 0.76 | GALR3 (0.52) | KMT2ALMNAHTTGBA1KDM4E | |
| SCHEMBL3956552 | 0.70 | ATR (0.43) | APPL3MBTL1HTTKDM4E | |
| SCHEMBL15757505 | 0.70 | HRH4 (0.47) | APPLMNAHTT | |
| SCHEMBL2905797 | 0.70 | METAP1 (1.00) | APPJAK2METAP1PPP1CAKMT2A | |
| SCHEMBL8497590 | 0.70 | APP (1.00) | APPKMT2AMAPK1EGFRLMNA | |
| SCHEMBL7918710 | 0.68 | CYP3A4 (0.53) | KMT2ALMNAKDM4E | |
| SCHEMBL7502035 | 0.67 | HTR1A (0.75) | APPKMT2AMAPK1EGFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051493-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |