Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.65 |
| ▸ | TPH1 | P17752 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PCNA | P12004 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL3955897 | 1.00 | SLC7A5 (0.65) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL160738 | 0.90 | SLC7A5 (0.80) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL160737 | 0.90 | SLC7A5 (0.80) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL27681068 | 0.84 | SLC7A5 (0.80) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL21800385 | 0.81 | SLC7A5 (0.86) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL7646268 | 0.81 | SLC7A5 (0.92) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL1639829 | 0.81 | SLC7A5 (0.92) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL8024711 | 0.81 | SLC7A5 (0.92) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL10978820 | 0.81 | SLC7A5 (1.00) | SLC7A5TPH1PTGS1ALPIPKM | |
| Tyrosine SCHEMBL11676395 | 0.81 | SLC7A5 (1.00) | SLC7A5TPH1PTGS1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200222492-A1 | Method of Reducing Injury to Mammalian Cells | NONO INC. (CA) | 2020-07-16 | — | — | US | disclosed |
| US-20180369319-A1 | Method of Reducing Injury to Mammalian Cells | NONO INC (CA) | 2018-12-27 | — | — | US | disclosed |
| US-20170239316-A1 | Method Of Reducing Injury To Mammalian Cells | NONO INC (CA) | 2017-08-24 | — | — | US | disclosed |
| US-20150190459-A1 | Method Of Reducing Injury To Mammalian Cells | NONO INC (CA) | 2015-07-09 | — | — | US | disclosed |
| US-20120302504-A1 | Method Of Reducing Injury To Mammalian Cells | NONO, INC. (CA) | 2012-11-29 | — | — | US | disclosed |
| US-8071548-B2 | Method of reducing injury to mammalian cells | NONO, INC. (CA) | 2011-12-06 | — | — | US | disclosed |
| US-20090298747-A1 | Methods and Compositions For Treatment of Nitric Oxide-Induced Clinical Conditions | BIO HOLDING, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090281037-A1 | Method of Reducing Injury to Mammalian Cells | NONO INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| US-7510824-B2 | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord | NONO INC. (CA) | 2009-03-31 | — | — | US | disclosed |
| US-20070224671-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2007-09-27 | — | — | US | disclosed |
| US-20050059597-A1 | Method of reducing injury to mammalian cells | 2056954 ONTARIO LTD. (CA) | 2005-03-17 | — | — | US | disclosed |
| US-20040220239-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20040220242-A1 | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20040220113-A1 | Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions | BIO HOLDING, INC. | 2004-11-04 | — | — | US | disclosed |
| US-6489308-B1 | ONE AGENT EXHIBITING MAMMALIAN ALPHA 1-ANTITRYPSIN OR ALPHA 1-ANTITRYPSIN-LIKE ACTIVITY, AND A FREE RADICAL SCAVENGER SUCH AS 2,6,8-TRIHYDROXYPURINE, DIHYDRORHODAMINE, OR A COMBINATION THEREOF | TRUSTEES OF UNIVERSITY OF TECHNOLOGY CORPORATION | 2002-12-03 | — | — | US | disclosed |