Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.80 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | XIAP | P98170 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TPH1 | P17752 | 1/20 | 0.50 |
| ▸ | GRB2 | P62993 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL160738 | 1.00 | SLC7A5 (0.80) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL27681068 | 0.93 | SLC7A5 (0.80) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL3955897 | 0.90 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL3955902 | 0.90 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL11676367 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL638520 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL11520041 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1580 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1581 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL11676395 | 0.89 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 400 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850233-A | Method for preparing tyrosine nitrate | TIANJIN TIANCHENG PHARMACEUTICAL CO LTD | 2013-01-02 | — | — | CN | claimed |
| EP-4712998-A1 | DUAL-DOMAIN PEPTIDE FOR DEPLETING HMGB1 FROM THE CIRCULATION VIA LIVER HSPG SYSTEM | The Medical College of Wisconsin (US) | 2026-03-25 | — | — | EP | disclosed |
| EP-4605401-A1 | 1H-PYRAZOLE ANALOGUES AND METHODS AND USES THEREOF | University of Manitoba (CA) | 2025-08-27 | — | — | EP | disclosed |
| WO-2024238337-A1 | DUAL-DOMAIN PEPTIDE FOR DEPLETING HMGB1 FROM THE CIRCULATION VIA LIVER HSPG SYSTEM | THE MEDICAL COLLEGE OF WISCONSIN (US) | 2024-11-21 | — | — | WO | disclosed |
| EP-3431480-B1 | DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE | UNIV HONG KONG (CN) | 2024-07-03 | — | — | EP | disclosed |
| WO-2024103151-A1 | 1H-PYRAZOLE ANALOGUES AND METHODS AND USES THEREOF | UNIVERSITY OF MANITOBA (CA) | 2024-05-23 | — | — | WO | disclosed |
| US-11965851-B2 | Grid coatings for capture of proteins and other compounds | PURDUE RESEARCH FOUNDATION (US) | 2024-04-23 | — | — | US | disclosed |
| US-20210041388-A1 | GRID COATINGS FOR CAPTURE OF PROTEINS AND OTHER COMPOUNDS | PURDUE RESEARCH FOUNDATION | 2021-02-11 | — | — | US | disclosed |
| EP-3689364-A1 | METHODS FOR THE USE OF PROGESTOGEN AS A GLUCOCORTICOID SENSITIZER | Shenzhen Evergreen Therapeutics Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |
| US-20200222492-A1 | Method of Reducing Injury to Mammalian Cells | NONO INC. (CA) | 2020-07-16 | — | — | US | disclosed |
| US-5849782-A | Methods of inhibiting neurodegenerative diseases | THE GENERAL HOSPITAL CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1998020736-A1 | VASOACTIVE EFFECTS AND FREE RADICAL GENERATION BY β-AMYLOID PEPTIDES | UNIVERSITY OF SOUTH FLORIDA (US) | 1998-05-22 | — | — | WO | disclosed |
| WO-1997033609-A1 | VASOACTIVE EFFECTS AND FREE RADICAL GENERATION BY β-AMYLOID PEPTIDES | UNIVERSITY OF SOUTH FLORIDA (US) | 1997-09-18 | — | — | WO | disclosed |
| EP-0729356-A1 | USE OF NITRIC OXIDE SYNTHASE INHIBITORS IN THE TREATMENT OF AUTOIMMUNE DISEASES | DUKE UNIVERSITY MEDICAL CENTER (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1996021445-A1 | METHODS OF INHIBITING NEURODEGENERATIVE DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 1996-07-18 | — | — | WO | disclosed |
| WO-1995013805-A1 | USE OF NITRIC OXIDE SYNTHASE INHIBITORS IN THE TREATMENT OF AUTOIMMUNE DISEASES | DUKE UNIVERSITY MEDICAL CENTER (US) | 1995-05-26 | — | — | WO | disclosed |
| EP-0557417-A4 | COMPOSITIONS FOR REDUCING OXIDATIVE INJURY | UAB RESEARCH FOUNDATION (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5277908-A | Modified superoxide dismutase | THE UAB RESEARCH FOUNDATION (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0557417-A1 | COMPOSITIONS FOR REDUCING OXIDATIVE INJURY | THE UAB RESEARCH FOUNDATION (US) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008482-A1 | COMPOSITIONS FOR REDUCING OXIDATIVE INJURY | UAB RESEARCH FOUNDATION (US) | 1992-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11965851-B2 | Grid coatings for capture of proteins and other compounds | CD2BP2, CDC37, CD68 | SLC7A5 4298/4885PTGS1 4745/4885ALPI 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.