Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levopropranolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 9/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 8/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 6/20 | 1.00 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | HTR2C | P28335 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HTR6 | P50406 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | SCN1A | P35498 | 2/20 | 1.00 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propranolol SCHEMBL10537386 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL1561135 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL12264958 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Dexpropranolol SCHEMBL29577201 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL3955 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Dexpropranolol SCHEMBL25255 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Levopropranolol SCHEMBL29355940 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL6511347 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL22291223 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1CYP2D6ADRB3NR2E1 | |
| Propranolol SCHEMBL20486000 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1CYP2D6ADRB3NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 83199 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122075410-A | Dry powder composition for intranasal delivery | — | 2026-05-26 | — | — | CN | claimed |
| CN-122070912-A | Application of propranolol or pharmaceutically acceptable salt thereof in preparation of medicines for inhibiting lung cancer meningal metastasis | 中国科学院广州生物医药与健康研究院 | 2026-05-22 | — | — | CN | claimed |
| US-20260137650-A1 | MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC (CA) | 2026-05-21 | — | — | US | claimed |
| CN-122031290-A | Percutaneous permeation promoting system and preparation method and application thereof | 北京工商大学 | 2026-05-15 | — | — | CN | claimed |
| WO-2026102339-A1 | ARTIFICIAL INTELLIGENCE-BASED METHOD AND SYSTEM FOR RAPID DRUG SCREENING USING INTRACELLULAR ELECTRICAL RECORDINGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-15 | — | — | WO | claimed |
| US-12622884-B2 | Treatment and prevention of glioblastoma | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2026-05-12 | — | — | US | claimed |
| CN-122005630-A | Extraction method of Cordyceps pseudoblack and medicinal application of extract thereof | 山西大学 | 2026-05-12 | — | — | CN | claimed |
| WO-2026090164-A1 | COMPOSITIONS COMPRISING ELISMETREP AND A SECOND THERAPEUTIC AGENT FOR TREATING OR PREVENTING MIGRAINE OR PAIN | KALLYOPE, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| US-4232029-A | 1-Hydroxyimidazole-5-methanamine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-04 | — | — | US | claimed |
| US-4226860-A | Spiroindolones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-10-07 | — | — | US | claimed |
| WO-1979001037-A1 | 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES | AMERICAN HOME PROD (US) | 1979-11-29 | — | — | WO | claimed |
| EP-0005365-A1 | Pyrano and thiopyrano (3,4-b) indole derivatives, processes for their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-11-14 | — | — | EP | claimed |
| EP-0005057-A1 | A material and composition for reducing blood pressure | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1979-10-31 | — | — | EP | claimed |
| US-4138475-A | Sustained release pharmaceutical composition | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-06 | — | — | US | claimed |
| US-4070492-A | ANTIGENS, ANTIBODIES, HAPTEN | HOFFMANN-LA ROCHE, INC. (US) | 1978-01-24 | — | — | US | claimed |
| US-4026879-A | HAPTENS | HOFFMANN-LA ROCHE INC. (US) | 1977-05-31 | — | — | US | claimed |
| US-4022893-A | Treatment for hypertension | MOYER JOHN H | 1977-05-10 | — | — | US | claimed |
| US-3947592-A | Treatment of opiate addiction | INDIANA UNIVERSITY FOUNDATION (US) | 1976-03-30 | — | — | US | claimed |