SCHEMBL3956404

SCHEMBL3956404

C1CC[SiH2]OC1.COC(=O)C1(O)c2ccccc2-c2ccc(Cl)cc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 6/20 0.38
F2 P00734 3/20 0.35
CHRM3 P20309 2/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
GAA P10253 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
MAPT P10636 2/20 0.33
NPC1 O15118 1/20 0.33
S1PR4 O95977 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
HSP90AA1 P07900 1/20 0.33
XBP1 P17861 1/20 0.33
S1PR1 P21453 1/20 0.33
NTSR1 P30989 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HKDC1 Q2TB90 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL124841 0.84 PDK2 (0.50) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL29359326 0.84 PDK2 (0.50) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL8827312 0.84 PDK2 (0.50) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL8539410 0.80 THRB (0.55) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL1982326 0.78 PDK2 (0.47) PDK2GAALMNASMN1; SMN2AKR1A1
SCHEMBL29827101 0.78 PDK2 (0.47) PDK2GAALMNASMN1; SMN2AKR1A1
SCHEMBL2097489 0.77 PDK2 (0.43) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL29663083 0.72 THRB (0.59) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL3245527 0.72 THRB (0.59) PDK2CHRM3CHRM2CHRM1GAA
SCHEMBL6925309 0.71 F2 (0.47) PDK2F2CHRM3CHRM2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7562831-B2 Snowmaking process AQUATROLS CORPORATION OF AMERICA, INC. (US) 2009-07-21 US disclosed
US-20030006291-A1 Snowmaking process ALDINE CAPITAL FUND II, L.P. 2003-01-09 US disclosed
US-6464148-B1 Snowmaking process AQUATROLS HOLDING CO., INC. 2002-10-15 US disclosed