Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747753 | 0.86 | OPRD1 (0.41) | OGASCN9AGRM5 | |
| SCHEMBL3956506 | 0.85 | MAP4K4 (0.39) | OGAJAK2JAK1PIK3CDGRM5 | |
| SCHEMBL3960271 | 0.80 | KCNH2 (0.41) | SCN9AKCNH2 | |
| SCHEMBL5750818 | 0.78 | GRM5 (0.41) | OGASCN9AGRM5 | |
| SCHEMBL1148210 | 0.76 | KCNH2 (0.39) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1148209 | 0.76 | KCNH2 (0.39) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1148213 | 0.76 | KCNH2 (0.39) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3695758 | 0.73 | KCNH2 (0.35) | OGAKCNH2 | |
| SCHEMBL5265774 | 0.70 | KCNH2 (0.41) | KCNH2JAK2JAK1 | |
| SCHEMBL3956031 | 0.68 | JAK2 (0.37) | JAK2JAK1KITHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784410-A4 | ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2009-07-15 | — | — | EP | disclosed |
| EP-1784410-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006020561-A2 | ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |