Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.55 |
| ▸ | JAK3 | P52333 | 13/20 | 0.55 |
| ▸ | JAK1 | P23458 | 9/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906571 | 0.87 | JAK2 (0.73) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL3956469 | 0.87 | JAK2 (0.59) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL3958691 | 0.79 | JAK2 (0.54) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL3954596 | 0.78 | JAK2 (0.60) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL30051224 | 0.75 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL3955441 | 0.75 | JAK2 (0.62) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL2866901 | 0.75 | JAK2 (0.81) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL13906566 | 0.74 | JAK2 (0.78) | JAK2JAK3JAK1HDAC1TYK2 | |
| SCHEMBL2859065 | 0.74 | JAK2 (0.58) | JAK2JAK3JAK1HDAC1HDAC6 | |
| SCHEMBL3961025 | 0.74 | JAK2 (0.60) | JAK2JAK3JAK1HDAC1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029998-A1 | RETROMETABOLIC COMPOUNDS | CYTOPIA RESEARCH PTY LTD (AU) | 2009-03-12 | — | — | WO | claimed |
| WO-2009029998-A1 | RETROMETABOLIC COMPOUNDS | CYTOPIA RESEARCH PTY LTD (AU) | 2009-03-12 | — | — | WO | disclosed |