Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743797 | 1.00 | PIN1 (0.54) | PIN1HTR2AHTR2BHTR2CAVPR2 | |
| SCHEMBL1519784 | 0.82 | EGFR (0.47) | EGFRKMT2ALMNACYP3A4PPARG | |
| SCHEMBL2548016 | 0.82 | ATM (0.51) | PIN1HTR2AHTR2BHTR2CAVPR2 | |
| SCHEMBL2548015 | 0.82 | ATM (0.51) | PIN1HTR2AHTR2BHTR2CAVPR2 | |
| SCHEMBL4901923 | 0.82 | ATM (0.51) | PIN1HTR2AHTR2BHTR2CAVPR2 | |
| SCHEMBL2546712 | 0.80 | HTR2A (0.49) | PIN1HTR2AHTR2BHTR2CMAPT | |
| SCHEMBL3959317 | 0.78 | MAPK1 (0.68) | PIN1EGFRMAPTMEN1KMT2A | |
| SCHEMBL3897966 | 0.78 | MAPK1 (0.68) | PIN1EGFRMAPTMEN1KMT2A | |
| SCHEMBL2973301 | 0.78 | MAPK1 (0.68) | PIN1EGFRMAPTMEN1KMT2A | |
| SCHEMBL14860568 | 0.78 | MAPK1 (0.49) | PIN1EGFRKMT2ACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032651-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |