Dacarbazine

Dacarbazine

SCHEMBL3957404

CN(C)/N=N/c1[nH]cnc1C(N)=O.[Pt]

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PAX8 Q06710 3/20 0.57
LMNA P02545 2/20 0.57
TSHR P16473 2/20 0.57
KDM4E B2RXH2 2/20 0.57
ALDH1A1 P00352 2/20 0.57
MMP9 P14780 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
MAPT P10636 2/20 0.37
PKM P14618 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
GDA Q9Y2T3 1/20 0.35
PARP1 P09874 1/20 0.30
CYP1A2 P05177 1/20 0.30
HSP90AA1 P07900 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dacarbazine SCHEMBL28242658 1.00 PAX8 (0.57) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL28292158 0.98 PAX8 (0.56) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL12591753 0.98 PAX8 (0.59) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL5560 0.98 PAX8 (0.59) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL1586950 0.98 PAX8 (0.59) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL6372 0.98 PAX8 (0.59) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL29042921 0.97 PAX8 (0.57) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL28074490 0.97 PAX8 (0.57) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL28074492 0.97 PAX8 (0.57) PAX8LMNATSHRKDM4EALDH1A1
Dacarbazine SCHEMBL28090782 0.97 PAX8 (0.57) PAX8LMNATSHRKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108498796-A A kind of novel PD-1 tumour immunities inhibitor and its process for preparing medicine 河南天晟泰丰医药科技有限公司 2018-09-07 CN disclosed
US-20160206717-A1 STIMULATION OF IMMUNITY TO ENDOTHELIAL CELLS, ENDOTHELIAL-LIKE CELLS, AND INTRATUMOR VASCULAR CHANNELS DERIVED FROM TUMOR TISSUE BATU BIOLOG INC (US) 2016-07-21 US disclosed
EP-1551388-A4 COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH SIGNAL PHARM INC (US) 2009-07-15 EP disclosed
EP-1996020-A2 PURINE COMPOUNDS AND METHODS OF USE THEREOF Inotek Pharmaceuticals Corporation (US) 2008-12-03 EP disclosed
WO-2007111954-A2 PURINE COMPOUNDS AND METHODS OF USE THEREOF INOTEK PHAMACEUTICALS CORPORATION (US) 2007-10-04 WO disclosed
EP-1802316-A2 PURINE DERIVATIVES AND METHODS OF USE THEREOF Inotek Pharmaceuticals Corporation (US) 2007-07-04 EP disclosed
EP-1644323-A4 HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF UNIV GEORGETOWN (US) 2007-06-20 EP disclosed
EP-1692128-A1 INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS Signal Pharmaceuticals LLC (US) 2006-08-23 EP disclosed
EP-1390393-A4 PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO SEATTLE GENETICS INC (US) 2006-05-24 EP disclosed
EP-1644323-A2 HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF GEORGETOWN UNIVERSITY (US) 2006-04-12 EP disclosed
WO-2006034190-A2 PURINE DERIVATIVES AND METHODS OF USE THEREOF INOTEK PHARMACEUTICALS CORPORATION (US) 2006-03-30 WO disclosed
EP-1551388-A2 COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH Signal Pharmaceuticals, Inc. (US) 2005-07-13 EP disclosed
WO-2005051942-A1 INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS SIGNAL PHARMACEUTICALS, LLC (US) 2005-06-09 WO disclosed
WO-2005007091-A2 HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF GEORGETOWN UNIVERSITY (US) 2005-01-27 WO disclosed
EP-1390393-A2 PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO Seattle Genetics, Inc. (US) 2004-02-25 EP disclosed
WO-2003105774-A2 COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH SIGNAL PHARMACEUTICALS, INC. (US) 2003-12-24 WO disclosed
WO-2002088172-A2 PENTAPEPTIDE COMPOUNDS AND USES RELATED THERETO SEATTLE GENETICS, INC. (US) 2002-11-07 WO disclosed